Iatrogenic Osteomalacia: Report of Two Cases

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  • YAMAMOTO Sunao
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
  • OKADA Yosuke
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
  • MORI Hiroko
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
  • KUROZUMI Akira
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
  • TORIMOTO Keiichi
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
  • ARAO Tadashi
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
  • TANAKA Yoshiya
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

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  • 医原性骨軟化症の２例

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Abstract

Case 1: An 80-year-old man presented at our hospital with pain in both knees.He had received continuous intravenous administration of saccharated ferric oxide (SFO) over a period of five years following a diagnosis of iron-deficiency anemia.Blood tests revealed hypophosphatemia (1.4 mg/dl) and high circulating levels of fibroblast growth factor 23 (FGF23) at 248.8 mg/dl.These findings led to the diagnosis of FGF23-related osteomalacia due to SFO administration.Accordingly, the treatment plan was first to discontinue SFO, which led to a decrease in pain and normalization of phosphorus and FGF23 after 1 month.Case 2: A 63-year-old woman presented at our hospital with leg pain.She had undergone total gastrectomy for gastric cancer at 36 years of age.Blood tests revealed hypocalcemia (8.3 mg/dl) and hypophosphatemia (2.2 mg/dl), and 25(OH)D at no more than 5 pg/ml.Bone X-rays showed significantly diminished bone shadowing.These findings led to a diagnosis of vitamin D-deficient osteomalacia due to impaired absorption following total gastrectomy.For therapy, she was treated with 1 μg/day oral alfacalcidol.Two months after initiating treatment, the pain improved.Conclusion: When a patient is diagnosed with unexplained pain, it is important to pay attention to the possibility of an iatrogenic etiology.

Journal

  • Journal of UOEH

    Journal of UOEH 35 (1), 25-31, 2013

    The University of Occupational and Environmental Health, Japan

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