Nuclear Factor-kappa B Is Not Involved in Titanium DioxideInduced Inflammation

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  • WILSON Donald
    Department of Occupational Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan.
  • ZAQOUT Mazen
    Department of Occupational Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan.
  • HEO Jeong-Hoon
    Department of Molecular Biology & Immunology, Kosin University College of Medicine
  • PARK Eun-Kee
    Department of Medical Humanities and Social Medicine, Kosin University College of Medicine
  • OAK Chul-Ho
    Department of Respiratory Medicine, Kosin University, Korea, Kosin University College of Medicine
  • UENO Susumu
    Department of Occupational Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan.

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Other Title
  • 二酸化チタンナノ粒子が誘導する炎症反応に核内因子κBが関与していない

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Abstract

Research over recent years have shown that titanium dioxide (TiO2) nanoparticles (NPs) induce inflammation in various lung, kidney, liver and brain cells. Although the mechanism of inflammation is unclear, existing literature suggests the underlying role of oxidative stress. On the other hand, it has also been shown that nuclear factor-kappa B (NFκB) is activated in response to pro-inflammatory cytokines. In this study we investigated the involvement of NF-κB in TiO2-induced inflammation in human lung adenocarcinomic epithelial cells (A549 cells). After 24h of treatment, IL-8 protein release from A549 cells, induced by 10, 50 and 250 μg/ml of P25 TiO2 NPs, were statistically significantly raised, compared to that of the control. This finding corroborates existing literature in that TiO2 NPs induce a dose-dependent increase in the release of IL-8 protein when exposed to A549 cells. However, the binding of NF-κB DNA was not affected after 6 h of incubation with P25. Therefore, NF-κB DNA binding is not the likely transcription pathway that leads to TiO2-induced inflammation.

Journal

  • Journal of UOEH

    Journal of UOEH 34 (2), 183-191, 2012

    The University of Occupational and Environmental Health, Japan

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