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A Case of Depression Manifesting Incessant Pacing and Wandering following Discontinuation of Antipsychotic Drugs due to Neuroleptic Malignant Syndrome: A Possible Involvement of Withdrawal Akathisia
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- WATANABE Haruo
- Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health
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- TERAO Takeshi
- Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health
Bibliographic Information
- Other Title
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- 悪性症候群発症に際し抗精神病薬を中断した後, 持続的な重度の徘徊が出現したうつ病の1例：離脱性アカシジア関与の可能性について
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Description
A depressed 36-year-old woman manifesting a delusion of persecution was started on neuroleptics. In parallel with the increase of neuroleptics, she suffered from akathisia, such as wandering, and thereafter developed neuroleptic malignant syndrome. Thus, neuroleptics were discontinued. As a result, she manifested severer wandering, impairment of conversation, and unacceptable behavior (e.g. touching her stool) though neuroleptic malignant syndrome subsided. These symptoms improved following the administration of levomepromazine and amitriptyline. It seems difficult to regard these symptoms as just a prolongation of akathisia, since the level and frequency of akathisia increased. It also seems unlikely to regard these symptoms as those of agitated depression, since there were no complaints of irritability. On the other hand, it seems probable that "withdrawal akathisia" occurred following the discontinuation of neuroleptics and the reinstituted levomepromazine improved the withdrawal phenomena consisting of severer wandering, impairment of conversation, and unacceptable behavior.
Journal
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- Journal of UOEH
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Journal of UOEH 19 (1), 29-38, 1997
University of Occupational and Environmental Health, Japan