マウス皮下に接種された鼠癩菌の菌長の変化

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タイトル別名
  • Changes in Length of Murine Leprosy Bacilli in Subcutaneous Tissue of Mice
  • マウス ヒカ ニ セッシュサレタ ネズミライキン ノ キンチョウ ノ ヘンカ

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Mice of 5 strains (C3H, BALB/c, KK, DDD and C57BL/6) were inoculated subcutaneously in the back wtih 0.25 ml of a 1:1000 suspension prepared from malignant leproma (Hawaiian strain). By electron microscopy, measurments of bacillary length were made on the bacilli recovered from the subcutaneous tissues at the inoculation site at varying time intervals and solid ratio of the bacilli was also culculated. Distribution of these bacilli was figured on the basis of bacillary length, ranging from 0.75μ to 6.0μ, as shown in Figs. 1 and 3.<br>In the bacillary length, there were no significant differences among these 5 strains during the first 2 weeks. Elongation of the bacilli was evident at 2 weeks. In C3H mice mean length of the bacilli began to decrease 4 weeks after infection and reached a constant level similar to that of the initials in 8 to 10 weeks. On the other hand, mean length of the bacilli in DDD and C57BL/6 mice reached maximum size at 2 to 4 weeks and maintained rather longer forms throughout the observation period, showing somewhat decrease in the length. The mean lengths in BALB/c and KK mice showed intermediate values, being nearer to those in DDD and C57BL/ 6 mice.<br>Solid ratio of the 5 strains of mice was decreased in 1 week and somewhat increased in 2 weeks. Thereafter, solid ratio of the bacilli in C3H mice increased gradually and, in 8 to 10 weeks, reached a high level as that of the bacilli recovered from fully established malignant leproma. In contrast, the solid ratio in the other 4 strains showed constant levels similar to those of the established benign leproma, in 4 to 10 weeks.<br>These differences became more remarkable from the observations on distribution curves of bacillary length among these mouse strains. Especially, pronounced differences were found between C3H and C57BL/6 mice in the distribution curves, being a highly peaked curve with narrow range and a flattened one with wide range, respectively.

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