Pathophysiology of Functional Dyspepsia

  • Futagami Seiji
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
  • Shimpuku Mayumi
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
  • Yin Yan
    Division of Gastroenterology, Department of Internal Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province
  • Shindo Tomotaka
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
  • Kodaka Yasuhiro
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
  • Nagoya Hiroyuki
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
  • Nakazawa Shoko
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
  • Fujimoto Mayumi
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
  • Izumi Nikki
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
  • Ohishi Noriko
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
  • Kawagoe Tetsuro
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
  • Horie Akane
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
  • Iwakiri Katsuhiko
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
  • Sakamoto Choitsu
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School

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Abstract

Functional dyspepsia is a highly prevalent and heterogeneous disorder. Functional dyspepsia involves many pathogenic factors, such as gastric motility disorders, visceral hypersensitivity, psychological factors, Helicobacter pylori infection, and excessive gastric acid secretion. The present article provides an overview of pathogenetic factors and pathophysiologic mechanisms.<br>

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