Autologous Bone Marrow Mononuclear Cell Implantation Induces Angiogenesis and Bone Regeneration in a Patient With Compartment Syndrome

  • Umemura Takashi
    Departments of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences
  • Nishioka Kenji
    Departments of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences
  • Igarashi Akira
    Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences
  • Kato Yukio
    Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences
  • Ochi Mitsuo
    Orthopaedic Surgery, Hiroshima University Graduate School of Biomedical Sciences
  • Chayama Kazuaki
    Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences
  • Yoshizumi Masao
    Departments of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences
  • Higashi Yukihito
    Departments of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences

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Other Title
  • Autologous bone marrow mononuclear cell implantation induces angiogenesis and bone formation in a patient with compartment syndrome.

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Description

A 28-year-old man developed compartment syndrome in the right lower leg after fracture of the tibia and fibula. Despite fasciotomy, many arteries collapsed and union of the tibial and fibula fractures did not occur. Autologous bone marrow mononuclear cell (BMMNC) implantation for therapeutic angiogenesis and subsequent bone regeneration was performed and 4 weeks later, angiography showed a marked increase in collateral vessels surrounding the tibial fracture, and union was completed 6 months later. BMMNC implantation therapy might provide therapeutic angiogenesis and osteogensis in patients with compartment syndrome. (Circ J 2006; 70: 1362 - 1364)<br>

Journal

  • Circulation Journal

    Circulation Journal 70 (10), 1362-1364, 2006

    The Japanese Circulation Society

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