MD simulation of asymmetric phospholipid bilayers with ions and cholesterols

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  • Mori Kenichi
    Graduate School of Pharmaceutical Sciences, Chiba University
  • Hata Masayuki
    Graduate School of Pharmaceutical Sciences, Chiba University
  • Neya Saburo
    Graduate School of Pharmaceutical Sciences, Chiba University
  • Hoshino Tyuji
    Graduate School of Pharmaceutical Sciences, Chiba University

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  • イオン濃度・コレステロール濃度を考慮した非対称性（POPC/POPE・POPS）リン脂質二重膜の分子動力学シミュレーション

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We report the molecular dynamics (MD) simulations of an asymmetric and mixed phospholipid bilayer with NaCl and cholesterols, and that with NaCl and no cholesterol. The extracellular sides of the membranes were constructed with phosphatidylcholine (POPC) molecules and the intracellular sides were phosphatidylethanolamine (POPE) and phosphatidylserine (POPS). The results showed that the cholesterol functioned to stabilize the phospholipid-mixed asymmetric membranes by making the lipid molecules more ordered and extended. In addition, it was revealed that the asymmetric feature affected the distribution of water molecules and the thickness of the membranes. The mixed phospholipid species dominated the ion distribution, such that Na+ ions were found more frequently on the intracellular side along the distribution of the POPS molecules. These results suggested that the asymmetric and mixed characters had a significant influence on the environment around the membrane, which would also affect the membrane proteins.

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