<i>In silico</i> Analysis of Interactions between Nevirapine-related Compounds, <i>HLA-B*14:02 </i>and T-cell Receptor<b> </b>
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- Isogai Hideto
- Department of Basic and Molecular Medicine, Tokai University School of Medicine
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- Hirayama Noriaki
- Institute of Advanced Biosciences, Tokai University
Bibliographic Information
- Other Title
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- ネビラピン関連化合物、<i>HLA-B*14:02</i>およびT細胞受容体相互作用の<i>in silico</i>解析
- In silico analysis of interactions between nevirapine-related compounds, HLA-B*14:02 and T-cell Receptor
Abstract
A non-nucleoside reverse-transcriptase inhibitor nevirapine (NVP) used to treat HIV-1 infection can cause severe, life-threatening idiosyncratic drug toxicity (IDT). It is known that the IDT caused by NVP or its metabolites is associated with the HLA-B*14:02 haplotype. The molecular mechanism of the HLA-associated IDT, however, has not been disclosed. In this study, we have simulated the interaction modes between NVP-related compounds, HLA B*14:02, and a T-cell receptor in order to understand the molecular mechanism leading to the onset of IDT.
Journal
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- Chem-Bio Informatics Journal
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Chem-Bio Informatics Journal 16 (0), 9-12, 2016-06-30
Chem-Bio Informatics Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282680078880128
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- NII Article ID
- 130005161358
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- ISSN
- 13470442
- 13476297
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed