Prevalence and Prognostic Implications of Pre-Diabetic State in Patients With Heart Failure

DOI Web Site 被引用文献1件 参考文献49件
  • Matsue Yuya
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Suzuki Makoto
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Nakamura Rena
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Abe Masami
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Ono Maki
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Yoshida Seigo
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Seya Mie
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Iwatsuka Ryota
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Mizukami Akira
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Setoguchi Masahiko
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Nagahori Wataru
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Ohno Masakazu
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Matsumura Akihiko
    Division of Cardiology, Department of Medicine, Kameda Medical Center
  • Hashimoto Yuji
    Division of Cardiology, Department of Medicine, Kameda Medical Center

この論文をさがす

説明

Background: Diabetes mellitus (DM) is a risk factor of poor prognosis in patients with heart failure (HF). The prevalence and prognostic impact of the pre-diabetic state, however, are not well understood. Methods and Results: One hundred and thirty-six consecutive patients admitted due to HF were included in this prospective study. The 75-g oral glucose tolerance test (OGTT) was performed in all patients without known DM, and patients were classified into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and DM groups. Forty-two of the 136 patients had previously been diagnosed with diabetes. Of the remaining 94 patients without known diabetes, 35 (37.2%) patients were classified as NGT, 9 (9.6%) as having IFG, 37 (39.4%) were classified as having IGT, and 13 (13.8%) were newly diagnosed with DM. During follow-up, patients with DM or IGT had significantly lower major adverse cardiac and cerebrovascular event (MACCE)-free rates than NGT patients (P=0.006, P=0.036, respectively). IFG, however, was not significantly related to increased MACCE risk. The presence of IGT (hazard ratio [HR], 4.51; P=0.011) and DM (HR, 4.74; P=0.005) were independent predictors of MACCE even after multivariate analysis. Conclusions: IGT and DM contribute to adverse prognosis in patients with HF. It is feasible to perform diabetes screening using OGTT in patients with HF for risk stratification. (Circ J 2011; 75: 2833-2839)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 75 (12), 2833-2839, 2011

    一般社団法人 日本循環器学会

被引用文献 (1)*注記

もっと見る

参考文献 (49)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ