Long-Term Outcome of Drug-Eluting vs. Bare-Metal Stents in Patients With Acute Myocardial Infarction

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  • Suzuki Susumu
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Ishii Hideki
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Matsudaira Kyoko
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Okumura Naoki
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Yoshikawa Daiji
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Hayashi Mutsuharu
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Maeda Kengo
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Kondo Takahisa
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Kondo Taizo
    Department of Cardiology, Komaki Municipal Hospital
  • Ichimiya Satoshi
    Department of Cardiology, Yokkaichi Municipal Hospital
  • Kato Rinya
    Department of Cardiology, Nagoya Ekisaikai Hospital
  • Matsubara Tatsuaki
    Department of Internal Medicine, School of Dentistry, Aichi-Gakuin University
  • Murohara Toyoaki
    Department of Cardiology, Nagoya University Graduate School of Medicine

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Other Title
  • – Subgroup Analysis of the Nagoya Acute Myocardial Infarction Study (NAMIS) –

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Background: The purpose of the present study was to compare the 5-year clinical outcomes after implantation of drug-eluting stent (DES) and bare-metal stent (BMS) in Japanese patients with acute myocardial infarction (AMI). Methods and Results: This study was a subgroup analysis of the Nagoya Acute Myocardial Infarction Study (NAMIS). It included 658 AMI patients, of which 280 were treated with a DES and 378 with a BMS. The major adverse cardiac event (MACE)-free rates during the 5-year follow-up period were similar between the 2 groups (95.7% vs. 96.8%, P=0.482). A significant difference was seen, however, in the target lesion revascularization (TLR) rates (7.9% vs. 17.7%, P<0.0001). Interestingly, there was no significant difference between the 2 groups from year 1 to 5 with regard to late TLR (2.5% vs. 2.1%, P=0.906), despite the markedly lower incidence of TLR within the first year in the DES group compared with the BMS group (5.4% vs. 15.6%, P<0.0001). Conclusions: In this long-term follow-up analysis of DES compared to BMS in Japanese patients with AMI, there was no significant difference in the incidence of MACE. Although a lower rate of TLR was observed in DES group within the first year, the superiority of DES in relation to the incidence of TLR disappeared after the first year following primary percutaneous coronary intervention.  (Circ J 2013; 77: 2024–2031)<br>

Journal

  • Circulation Journal

    Circulation Journal 77 (8), 2024-2031, 2013

    The Japanese Circulation Society

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