Relation of Apolipoprotein E Polymorphism to Markers of Early Atherosclerotic Changes in Young Adults The Cardiovascular Risk in Young Finns Study

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  • Grönroos Paula
    Department of Clinical Chemistry, University of Turku Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere
  • Raitakari Olli T.
    Department of Clinical Physiology, University of Turku
  • Kähönen Mika
    Department of Clinical Physiology, Tampere University Hospital
  • Hutri-Kähönen Nina
    Department of Paediatrics, Tampere University Hospital
  • Juonala Markus
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
  • Marniemi Jukka
    Department of Health and Functional Capacity, Population Research Laboratory, National Public Health Institute
  • Viikari Jorma
    Department of Medicine, University of Turku
  • Lehtimäki Terho
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere

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タイトル別名
  • The Cardiovascular Risk in Young Finns Study

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Background Carotid artery intima-media thickness (IMT), which is measured by ultrasound, is used in the assessment of early atherosclerotic changes, and has been associated with apolipoprotein E (APOE) polymorphism in many studies comprising elderly subjects. However, results are still inconclusive and data relating to young adults are missing. Whether common APOE polymorphism is related to carotid IMT was studied in a population of young adults. Also brachial flow-mediated dilatation (FMD) and carotid artery compliance (CAC) were determined to clarify their relation to this genetic factor. Methods and Results A total of 1,188 young adults (aged 24-39 years) participating in the Cardiovascular Risk in Young Finns Study with complete data of common APOE polymorphism underwent a carotid and brachial ultrasound. Patients' lipid levels and blood pressure were also examined. There was no significant association between the APOE phenotypes and carotid IMT, brachial FMD or CAC either in young men or in young women. The results were similar for systolic and diastolic blood pressure. In the same population, the well-known association between APOE phenotypes and lipids was seen. Conclusions Common APOE polymorphism does not seem to be an independent genetic determinant of carotid IMT, brachial FMD or CAC. (Circ J 2008; 72: 29 - 34)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 72 (1), 29-34, 2008

    一般社団法人 日本循環器学会

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