Smoking Promotes Subclinical Atherosclerosis in Apparently Healthy Men

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  • Sanada Shoji
    Health Care Center, Osaka University Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
  • Nishida Makoto
    Health Care Center, Osaka University Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
  • Ishii Kouki
    Health Care Center, Osaka University
  • Moriyama Toshiki
    Health Care Center, Osaka University
  • Komuro Issei
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
  • Yamauchi-Takihara Keiko
    Health Care Center, Osaka University Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

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  • – 2-Year Ultrasonographic Follow-up –

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Background: Smoking is a major risk factor for cardiovascular disease. Also, inflammatory activation and metabolic disorder are the mediators of smoking-induced atherosclerotic progression. The aim of the present study was to investigate whether current smoking and smoking cessation alter inflammatory or metabolic status and affect subclinical atherosclerosis in apparently healthy men. Methods and Results: Classical risk factors and smoking habit were evaluated in 354 men who completed health examinations annually without any current medications. Carotid intima-media thickness (IMT) was followed for 27.1±4.5 months. At baseline, both maximum and mean IMT significantly changed during 2-year follow-up. They tended to increase along with progression of smoking habit, with significantly greater maximum IMT in current smokers compared with never smokers. Both maximum and mean IMT significantly changed during 2-year follow-up, and tended to increase with progression of smoking habit, with maximum IMT being greatest for current smokers. Past smokers tended to have greater IMT increase than never smokers. Among smoking habit and some atherosclerotic risk markers that showed significant correlation with maximum IMT increase, stepwise regression showed that smoking habit and serum low-density lipoprotein-cholesterol (LDL-C) level were the only independent predictors. Conclusions: Significant 2-year progression of subclinical atherosclerosis was associated with continuous smoking and LDL-C. This was only partly moderated in past smokers despite complete reversal of inflammatory activation, suggesting another crucial factor for inhibiting accelerated progression of subclinical atherosclerosis in men.  (Circ J 2012; 76: 2884–2891)<br>

Journal

  • Circulation Journal

    Circulation Journal 76 (12), 2884-2891, 2012

    The Japanese Circulation Society

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