Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts prognosis after acute coronary syndrome—a pilot study
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- Kume Noriaki
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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- Mitsuoka Hirokazu
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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- Hayashida Kazutaka
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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- Tanaka Masaru
- Cardiovascular Center, Osaka Red Cross Hospital
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- Kita Toru
- Director, Kobe Medical Center General Hospital
書誌事項
- タイトル別名
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- Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Predicts Prognosis After Acute Coronary Syndrome - A Pilot Study -
- – A Pilot Study –
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説明
Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in atherosclerotic plaque vulnerability. It is shed, in part, by proteases and released as soluble LOX-1 (sLOX-1), which is a specific and sensitive biomarker of acute coronary syndrome (ACS). The present study explored if sLOX-1 can also predict prognosis after ACS. Methods and Results: ACS patients undergoing emergency percutaneous coronary intervention and measurement of circulating sLOX-1 were followed (median: 896 days). Among 94 patients, 13 had ACS recurrence or died (re-ACS/death group). None of age, sex, lipid profile or prevalence of diabetes, smoking or hypertension was significantly different between the re-ACS/death group and the event-free survival group. Circulating sLOX-1 levels, but not those of high-sensitivity C-reactive protein (hs-CRP) or troponin T (TnT), were significantly (P<0.005) higher in the re-ACS/death group than in the event-free survival group. Kaplan-Meier survival curves showed that ACS patients with sLOX-1 values in the highest quartile or tertile had more frequent and earlier ACS recurrence or death. Receiver-operating characteristic curves for prediction of re-ACS or death showed higher sensitivity and specificity for sLOX-1 (area under the curve for sLOX-1, hs-CRP and TnT: 0.764, 0.658 and 0.524, respectively). Conclusions: Circulating sLOX-1, a diagnostic biomarker of ACS, also predicts ACS recurrence or death. (Circ J 2010; 74: 1399 - 1404)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 74 (7), 1399-1404, 2010
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680080032640
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- NII論文ID
- 10030695638
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 使用不可