Tracking Serum Lipid Levels and the Association of Cholesterol Concentrations, Blood Pressure and Cigarette Smoking With Carotid Artery Intima-Media Thickness in Young Adults Born Small for Gestational Age

DOI Web Site 被引用文献4件 参考文献67件
  • Salonen Maria
    Department of Pediatrics, Kuopio University Hospital and University of Eastern Finland Department of Pediatrics, Kymenlaakso Central Hospital
  • Tenhola Sirpa
    Department of Pediatrics, Kymenlaakso Central Hospital
  • Laitinen Tomi
    Department of Clinical Physiology, Kuopio University Hospital
  • Lyyra-Laitinen Tiina
    Department of Clinical Physiology, Kuopio University Hospital
  • Romppanen Jarkko
    Eastern Finland Laboratory Centre and University of Eastern Finland
  • Jääskeläinen Jarmo
    Department of Pediatrics, Kuopio University Hospital and University of Eastern Finland
  • Voutilainen Raimo
    Department of Pediatrics, Kuopio University Hospital and University of Eastern Finland

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Background: Small birth size is associated with increased cardiovascular disease risk, but the mediating factors are poorly understood. Methods and Results: Serum lipids, blood pressure (BP), carotid artery intima-media thickness (CA-IMT), and brachial artery flow-mediated dilatation (BA-FMD) were studied in 70 20-year-old subjects [35 sex- and age-matched pairs born small (SGA) and appropriate for gestational age (AGA)]. The SGA subjects had higher serum levels of low-density lipoprotein (LDL) cholesterol, total/high-density lipoprotein (HDL) and LDL/HDL cholesterol ratios, and lower HDL cholesterol levels than the AGA subjects (2.71 vs 2.37mmol/L, P<0.05; 3.12 vs 2.80, P<0.01; 1.98 vs 1.61, P=0.002; 1.43 vs 1.56mmol/L, P<0.05, respectively). In the SGA group, total and LDL cholesterol levels correlated inversely with adult height SD score (r=0.463, P=0.006 and r=0.413, P=0.015, respectively). CA-IMT or BA-FMD did not differ between the groups, but cigarette smoking, higher diastolic BP, and shorter birth length associated with higher CA-IMT in the whole study population. A clear tracking of cholesterol levels was found from 12 to 20 years. Conclusions: SGA subjects had more unfavorable lipid profiles than the controls, the shortest having the highest LDL cholesterol. Cigarette smoking, higher diastolic BP, and shorter birth length associated with higher CA-IMT in the whole study population. A clear tracking of cholesterol levels through adolescence enables early targeting of lifestyle counseling for reducing cardiovascular disease risk. (Circ J 2010; 74: 2419-2425)<br>

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  • Circulation Journal

    Circulation Journal 74 (11), 2419-2425, 2010

    一般社団法人 日本循環器学会

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