Change of Coronary Flow by Continuous-Flow Left Ventricular Assist Device With Cardiac Beat Synchronizing System (Native Heart Load Control System) in Acute Ischemic Heart Failure Model

DOI Web Site PubMed 被引用文献12件 参考文献52件
  • Umeki Akihide
    Department of Cardiothoracic Surgery, The University of Tokyo Department of Artificial Organ, National Cerebral and Cardiovascular Center
  • Nishimura Takashi
    Department of Cardiothoracic Surgery, The University of Tokyo
  • Ando Masahiko
    Department of Cardiothoracic Surgery, The University of Tokyo
  • Takewa Yoshiaki
    Department of Artificial Organ, National Cerebral and Cardiovascular Center
  • Yamazaki Kenji
    Department of Cardiovascular Surgery, Tokyo Women’s Medical University
  • Kyo Shunei
    Department of Cardiothoracic Surgery, The University of Tokyo
  • Ono Minoru
    Department of Cardiothoracic Surgery, The University of Tokyo
  • Tsukiya Tomonori
    Department of Artificial Organ, National Cerebral and Cardiovascular Center
  • Mizuno Toshihide
    Department of Artificial Organ, National Cerebral and Cardiovascular Center
  • Taenaka Yoshiyuki
    Department of Artificial Organ, National Cerebral and Cardiovascular Center
  • Tatsumi Eisuke
    Department of Artificial Organ, National Cerebral and Cardiovascular Center

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Background: A novel control system for the EVAHEART left ventricular assist device (LVAD), known as the Native Heart Load Control System (NHLCS), can change the device’s rotational speed (RS) in synchrony with the heartbeat. The system enhanced coronary flow (CoF) with the counter-pulse mode in normal goats’ hearts, so we examined the change in CoF in goats with acute ischemic heart failure (HF). Methods and Results: We studied 14 goats (56.1±6.9kg) with acute ischemic HF induced by coronary microsphere embolization. We installed EVAHEART and ran the device in 4 modes [continuous support, circuit-clamp, counter-pulse (raise RS in diastole), and co-pulse (raise RS in systole)] with 50% or 100% bypass in each mode. In comparison with the circuit-clamp mode, CoF was 121.0±14.1% in the counter-pulse mode and 102.9±7.9% in the co-pulse mode, whereas it was 113.5±10.6% in the continuous mode, with 100% bypass (P<0.05). The same difference was confirmed with 50% bypass. The results indicated that a LVAD in an acute ischemic heart enhanced CoF, and that CoF was greater in the counter-pulse mode and smaller in the co-pulse mode relative to the continuous mode. Conclusions: By using NHLCS to change CoF, recovery of native heart function with a LVAD has a better prognosis.  (Circ J 2013; 77: 995–1000)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 77 (4), 995-1000, 2013

    一般社団法人 日本循環器学会

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