Impact of Diabetes Mellitus on Coronary Atherosclerosis and Plaque Composition Under Statin Therapy
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- Nozue Tsuyoshi
- Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital
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- Yamamoto Shingo
- Department of Cardiology, Tsurumi Nishiguchi Hospital
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- Tohyama Shinichi
- Department of Cardiology, Yokohama Seamen’s Insurance Hospital
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- Fukui Kazuki
- Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center
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- Umezawa Shigeo
- Department of Cardiology, Hiratsuka Kyosai Hospital
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- Onishi Yuko
- Department of Cardiology, Hiratsuka Kyosai Hospital
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- Kunishima Tomoyuki
- Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine
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- Sato Akira
- Cardiovascular Center, Yokosuka Kyosai Hospital
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- Nozato Toshihiro
- Department of Cardiology, National Hospital Organization, Disaster Medical Center
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- Miyake Shogo
- Department of Cardiology, Ebina General Hospital
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- Takeyama Youichi
- Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital
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- Morino Yoshihiro
- Department of Cardiology, Tokai University School of Medicine
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- Yamauchi Takao
- Department of Cardiology, Tokyo Women’s Medical University
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- Muramatsu Toshiya
- Department of Cardiology, Saiseikai Yokohama City Eastern Hospital
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- Hibi Kiyoshi
- Division of Cardiology, Yokohama City University Medical Center
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- Terashima Mitsuyasu
- Cardiovascular Imaging Center
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- Michishita Ichiro
- Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital
書誌事項
- タイトル別名
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- – Subanalysis of the TRUTH Study –
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説明
Background: Patients with diabetes mellitus (DM) have a markedly increased incidence of adverse cardiovascular events, but the mechanisms have not been well-characterized. Methods and Results: The TRUTH study evaluated the effects of 8-month statin therapy on coronary artery plaque composition using virtual histology intravascular ultrasound (IVUS). Analyzable IVUS data were obtained from 119 patients, including 50 DM patients. The pattern of arterial remodeling, extent of coronary atherosclerosis, and plaque composition were compared in subjects with and without DM. Significant decreases in atheroma volume (–2.3%, P=0.02) and external elastic membrane volume (–1.7%, P=0.02) were observed only in the non-DM group. Although statin therapy significantly decreased the fibro-fatty component in both groups, this component at follow-up was significantly greater in the DM group (0.99mm3/mm vs. 0.70mm3/mm, P=0.03). Multivariate regression analysis showed that the presence of DM was associated with greater atheroma volume (β=0.203, P=0.02), particularly fibro-fatty plaque volume at follow-up (β=0.215, P=0.01). Conclusions: DM attenuated the degree of regression of coronary atherosclerosis under statin therapy. A large amount of fibro-fatty plaque volume under statin therapy may affect the development of coronary events in patients with DM. (Circ J 2012; 76: 2188–2196)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 76 (9), 2188-2196, 2012
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680080188800
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- NII論文ID
- 10030696774
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- NII書誌ID
- AA11591968
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- COI
- 1:CAS:528:DC%2BC38XhtlOmsrvL
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- ISSN
- 13474820
- 13469843
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- PubMed
- 22785608
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
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