Serial Changes in Glucose-Loaded 18F-Fluoro-2-Deoxyglucose Positron Emission Tomography, 99mTc-Tetrofosmin and 123I-Beta-Methyl-p-Iodophenyl-Penta-Decanoic Acid Myocardial Single-Photon Emission Computed Tomography Images in Patients With Anterior Acute Myocardial Infarction

Momose Mitsuru

doi:10.1253/circj.cj-12-0011

Background: ¹⁸F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) is assumed to be the most useful method for evaluating the viability of the myocardium. However, there are few reports regarding serial changes in ¹⁸F-FDG-PET images of acute myocardial infarction (AMI). We evaluated serial changes in glucose-loaded ¹⁸F-FDG-PET, ¹²³I-β-methyl-p-iodophenyl-penta-decanoic acid (BMIPP) single-photon emission computed tomography (SPECT) and ^99mTc-Tetrofosmin (TF) gated SPECT images in patients with AMI. Methods and Results: We enrolled 7 consecutive patients with first anterior AMI who successfully underwent percutaneous coronary intervention (PCI). ¹⁸F-FDG-PET images were obtained in the acute, subacute, chronic, mid-term and long-term phases. ¹²³I-BMIPP and ^99mTc-TF SPECT images were obtained in the subacute, chronic, mid-term and long-term phases. We determined the total defect score (TDS) for each image. The TDS of the glucose-loaded ¹⁸F-FDG-PET, ¹²³I-BMIPP and^99mTc-TF SPECT images indicated significant serial decrease (P<0.001). Comparing these images, the TDS of the glucose-loaded ¹⁸F-FDG-PET images was larger than that of the ¹²³I-BMIPP and ^99mTc-TF SPECT images, and the TDS indicated ¹⁸F-FDG-PET>¹²³I-BMIPP>^99mTc-TF in all phases. Conclusions: The defect areas of glucose-loaded ¹⁸F-FDG-PET images were significantly larger than those of ¹²³I-BMIPP and^99mTc-TF SPECT images during 9 months follow-up of patients with successful PCI for anterior AMI. Additionally, the impairment of glucose metabolism was prolonged. (Circ J 2013; 77: 137–145)

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