Mechanisms of vein graft adaptation to the arterial circulation: insights into the neointimal algorithm and management strategies

DOI Web Site 被引用文献12件 参考文献227件
  • Muto Akihito
    Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine Section of Vascular Surgery, Yale University School of Medicine
  • Model Lynn
    Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine Section of Vascular Surgery, Yale University School of Medicine
  • Ziegler Kenneth
    Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine Section of Vascular Surgery, Yale University School of Medicine
  • Eghbalieh Sammy D.D.
    Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine St Mary's Hospital
  • Dardik Alan
    Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine Section of Vascular Surgery, Yale University School of Medicine The VA Connecticut Healthcare System

書誌事項

タイトル別名
  • Mechanisms of Vein Graft Adaptation to the Arterial Circulation
  • – Insights Into the Neointimal Algorithm and Management Strategies –

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説明

For patients with coronary artery disease or limb ischemia, placement of a vein graft as a conduit for a bypass is an important and generally durable strategy among the options for arterial reconstructive surgery. Vein grafts adapt to the arterial environment, and the limited formation of intimal hyperplasia in the vein graft wall is thought to be an important component of successful vein graft adaptation. However, it is also known that abnormal, or uncontrolled, adaptation may lead to abnormal vessel wall remodeling with excessive neointimal hyperplasia, and ultimately vein graft failure and clinical complications. Therefore, understanding the venous-specific pathophysiological and molecular mechanisms of vein graft adaptation are important for clinical vein graft management. Of particular importance, it is currently unknown whether there exist several specific distinct molecular differences in the venous mechanisms of adaptation that are distinct from arterial post-injury responses; in particular, the participation of the venous determinant Eph-B4 and the vascular protective molecule Nogo-B may be involved in mechanisms of vessel remodeling specific to the vein. This review describes (1) venous biology from embryonic development to the mature quiescent state, (2) sequential pathologies of vein graft neointima formation, and (3) novel candidates for strategies of vein graft management. Scientific inquiry into venous-specific adaptation mechanisms will ultimately provide improvements in vein graft clinical outcomes.  (Circ J 2010; 74: 1501 - 1512)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 74 (8), 1501-1512, 2010

    一般社団法人 日本循環器学会

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