Significant Increase in the Incidence of Ventricular Arrhythmic Events After an Intrathoracic Impedance Change Measured With a Cardiac Resynchronization Therapy Defibrillator

  • Sekiguchi Yukio
    Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Tada Hiroshi
    Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Yoshida Kentaro
    Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Seo Yoshihiro
    Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Li Shelby
    Medtronic, Inc
  • Tejima Tomoyuki
    Medtronic, Inc
  • Shoda Morio
    Department of Cardiology, Tokyo Women's Medical University
  • Kamakura Shiro
    Division of Cardiology, National Cerebral and Cardiovascular Center
  • Aonuma Kazutaka
    Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

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Abstract

Background: Cardiac resynchronization therapy defibrillator (CRT-D) devices are now capable of monitoring changes in intrathoracic impedance. Intrathoracic impedance monitoring resulting in a fluid index threshold crossing has been proven to predict heart failure (HF) exacerbations. We retrospectively investigated the relationship between changes in intrathoracic impedance and the occurrence of arrhythmic events. Methods and Results: From 282 patients with New York Heart Association class III or IV HF who were implanted with a CRT-D device with a fluid index feature based on intrathoracic impedance monitoring capabilities, arrhythmic events were retrospectively analyzed in terms of the threshold crossings. The patients were divided into 2 groups: those with fluid index threshold crossings and those without threshold crossings. A total of 4,725 tachyarrhythmic events were reported in 129 patients (46%), and there were 221 fluid index crossing events in 145 patients (51%) during 10.0±3.2 months. Tachyarrhythmic events were more frequently recorded in patients with threshold crossing events than in those who did not experience a threshold crossing (3,241 vs. 1,484 events, P<0.0001). Ventricular tachyarrhythmic events mainly occurred within the first 30 days after the threshold crossing event; however, a similar trend was not observed for the atrial tachyarrhythmic events. Conclusions: Intrathoracic impedance monitoring may predict arrhythmic events, especially ventricular arrhythmias, in patients with HF and provides an additional management tool. (Circ J 2011; 75: 2614-2620)<br>

Journal

  • Circulation Journal

    Circulation Journal 75 (11), 2614-2620, 2011

    The Japanese Circulation Society

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