Sex Difference in Peripheral Arterial Response to Cold Exposure

DOI Web Site 被引用文献7件 参考文献62件
  • Sato Fujio
    Department of Cardiovascular Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba
  • Matsushita Shonosuke
    Department of Cardiovascular Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba
  • Hyodo Kazuyuki
    High Energy Accelerator Research Organization
  • Akishima Shinji
    Department of Cardiovascular Surgery, Ibarakihigashi Hospital
  • Imazuru Tomohiro
    Department of Cardiovascular Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba
  • Tokunaga Chiho
    Department of Cardiovascular Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba
  • Enomoto Yoshiharu
    Department of Cardiovascular Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba
  • Kanemoto Shinya
    Department of Cardiovascular Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba
  • Hiramatsu Yuji
    Department of Cardiovascular Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba
  • Sakakibara Yuzuru
    Department of Cardiovascular Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba

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Background In Japan, there is a symptom commonly referred to as "Hie-sho", which is a feeling of coldness or chill in a particular part of the body, and it can sometimes be unendurable. This phenomenon is known to occur more frequently in women. The present study used synchrotron radiation micro-angiography (SRMA) to examine the hypothesis that this feeling is derived from a sex difference in the vascular response to coldness. Methods and Results The hind limb of male (Group M) and female (Group F) Wistar rats was exposed to cold and the tissue temperature was recorded. SRMA with a spatial resolution of 26 μm was used to measure arterial diameter. The reduction in temperature brought on by cold exposure was significantly larger in Group F than in Group M (p<0.05). SRMA showed that the arteries were dilated by cold exposure in both groups; however, the percentage dilatation in response was statistically small in Group F (69±40%) compared with Group M (118±73%) (p<0.05). Conclusion Arteries in the limbs of female rats did not expand as much as those of the males in response to cold exposure, which may explain why women feel the cold more than men. (Circ J 2008; 72: 1367 - 1372)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 72 (8), 1367-1372, 2008

    一般社団法人 日本循環器学会

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