Prognostic Effects of Calcium Channel Blockers in Patients With Vasospastic Angina - A Meta-Analysis -

DOI Web Site PubMed PubMed 被引用文献20件 参考文献41件 オープンアクセス
  • Nishigaki Kazuhiko
    Second Department of Internal Medicine, Gifu University Graduate School of Medicine
  • Inoue Yukiko
    Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital
  • Yamanouchi Yoshio
    Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital
  • Fukumoto Yoshihiro
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Yasuda Satoshi
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Sueda Shozo
    Department of Cardiology, Ehime Prefectural Niihama Hospital
  • Urata Hidenori
    Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital
  • Shimokawa Hiroaki
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Minatoguchi Shinya
    Second Department of Internal Medicine, Gifu University Graduate School of Medicine

書誌事項

タイトル別名
  • – A Meta-Analysis –

この論文をさがす

説明

Background: Although calcium channel blockers (CCB) are highly effective for suppression of vasospastic angina (VSA) attacks, their prognostic effects in VSA patients remain to be examined in a large number of patients. Methods and Results: Databases for related papers were searched and then a meta-analysis regarding the effects of CCB on major adverse cardiovascular events (MACE) in Japanese VSA patients with the 4 previous studies was performed. A total of 1,997 patients with positive coronary spasm provocation tests were evaluated. They were treated with either alone or combination of benidipine (n=320), amlodipine (n=308), nifedipine (n=182) or diltiazem (n=960). MACE were observed in 143 patients (cardiac death: 36, myocardial infarction: 51, heart failure: 26, stroke: 65, and aortic aneurysm: 11). The hazard ratio for the occurrence of MACE was significantly lower in patients treated with benidipine than in those with diltiazem. There was no significant difference in the clinical characteristics affecting the occurrence of MACE among the 4 CCB groups. Furthermore, the hazard ratio for the occurrence of MACE was significantly lower in those treated with benidipine, even after correction for patient characteristics that could have affected the occurrence of MACE (hazard ratio 0.41, P=0.016). Conclusions: These results suggest that among the 4 major CCB that effectively suppress VSA attacks in general, benidipine showed significantly more beneficial prognostic effects than others.  (Circ J 2010; 74: 1943 - 1950)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 74 (9), 1943-1950, 2010

    一般社団法人 日本循環器学会

被引用文献 (20)*注記

もっと見る

参考文献 (41)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ