Apolipoprotein A-I/C-III/A-IV SstI and Apolipoprotein B XbaI Polymorphisms Do not Affect Early Functional and Structural Changes in Atherosclerosis The Cardiovascular Risk in Young Finns Study

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  • Nieminen Tuomo
    Department of Pharmacological Sciences, Medical School, University of Tampere
  • Kähönen Mika
    Department of Clinical Physiology, Tampere University Hospital and Medical School
  • Islam Md. Shaheenul
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital, and Centre for Laboratory Medicine, Medical School, University of Tampere The George Institute for International Health
  • Raitakari Olli T.
    Department of Clinical Physiology, University of Turku
  • Hutri-Kähönen Nina
    Department of Paediatrics, Tampere University Hospital
  • Marniemi Jukka
    Department of Health and Functional Capacity, National Public Health Institute
  • Juonala Markus
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
  • Rontu Riikka
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital, and Centre for Laboratory Medicine, Medical School, University of Tampere
  • Viikari Jorma
    Department of Medicine, Turku University Hospital and University of Turku
  • Lehtimäki Terho
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital, and Centre for Laboratory Medicine, Medical School, University of Tampere

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  • The Cardiovascular Risk in Young Finns Study

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Background The present study was designed to investigate the effects of apoB XbaI and apoA-I/C-III/A-IV SstI polymorphisms to carotid artery intima - media thickness (IMT), carotid artery compliance (CAC) and brachial artery flow-mediated vasodilatation (FMD). Methods and Results As part of the Cardiovascular Risk in Young Finns Study, the carotid IMT, CAC and brachial FMD of 2,265 subjects (mean age ± SD 32 ±5 years) were measured with ultrasonography, and genotyping of the apolipoprotein polymorphisms was performed. The frequencies of the genotypes did not differ between the groups with high (above median 0.57 mm) and low (below median) IMT, CAC or FMD. The average carotid IMT differed between the 3 apoB XbaI genotypes (ANOVA, p=0.04), but not between the apoA-I/C-III/A-IV SstI genotypes (ANOVA, p=0.53). The relationship between the polymorphisms and carotid IMT was not significant in any of the covariate-adjusted logistic and linear regression analyses. CAC and FMD were not influenced by either of the polymorphisms in ANOVA and regression analyses. Conclusions The polymorphisms apoA-I/C-III/A-IV SstI and apoB XbaI do not seem to affect carotid artery characteristics or brachial artery FMD in young adulthood. (Circ J 2007; 71: 741 - 745)<br>

Journal

  • Circulation Journal

    Circulation Journal 71 (5), 741-745, 2007

    The Japanese Circulation Society

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