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- Shibata Rei
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Ouchi Noriyuki
- Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine
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- Murohara Toyoaki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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説明
Obesity is strongly associated with metabolic and cardiovascular disorders. Adiponectin is an adipose-derived plasma protein that is downregulated in subjects with obesity-related disorders. Low levels of adiponectin are associated with the increased prevalence of obesity-linked cardiovascular diseases, including ischemic heart disease and peripheral artery disease. Experimental findings have shown that adiponectin has beneficial effects in the cardiovascular system by directly acting on the component cells of the heart and blood vessels. Adiponectin protects cardiovascular tissues under conditions of stress through a number of mechanisms: inhibition of pro-inflammatory and hypertrophic responses, and stimulation of endothelial cell responses. These effects of adiponectin are mainly attributed to the modulation of signaling molecules, including AMP-activated protein kinase. Thus, adiponectin could be a promising therapeutic target for cardiovascular diseases. (Circ J 2009; 73: 608 - 614)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 73 (4), 608-614, 2009
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680081746816
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- NII論文ID
- 10025928845
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- NII書誌ID
- AA11591968
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- COI
- 1:CAS:528:DC%2BD1MXkslWnsrc%3D
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- ISSN
- 13474820
- 13469843
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- PubMed
- 19261992
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可
