Association of Interleukin-10 Level With Increased 30-Day Mortality in Patients With ST-Segment Elevation Acute Myocardial Infarction Undergoing Primary Coronary Intervention

DOI Web Site 被引用文献6件 参考文献36件
  • Yip Hon-Kan
    Division of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University Collage of Medicine
  • Youssef Ali A
    Cardiology Department, Suez Canal University Hospital
  • Chang Li-Teh
    Division of Basic Medical Science, Department of Nursing, Meiho Institute of Technology, Ping Tung
  • Yang Cheng-Hsu
    Division of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University Collage of Medicine
  • Sheu Jiunn-Jye
    Department of Cardiovascular Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University Collage of Medicine
  • Chua Sarah
    Division of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University Collage of Medicine
  • Yeh Kuo-Ho
    Division of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University Collage of Medicine
  • Lee Fan-Yen
    Department of Cardiovascular Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University Collage of Medicine
  • Wu Chiung-Jen
    Division of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University Collage of Medicine
  • Hang Chi-Ling
    Division of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University Collage of Medicine

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Background The prognostic value of interleukin (IL)-10 in patients with ST-segment elevation acute myocardial infarction (ST-se AMI) is currently unclear. The purpose of this study was to test whether the serum IL-10 level can predict 30-day mortality in patients with ST-se AMI undergoing primary percutaneous coronary intervention (PCI). Methods and Results The study design was a prospective cohort study of 250 consecutive patients with ST-se AMI of onset <12 h who were undergoing primary PCI. Blood samples for serum IL-10 levels were collected in the catheterization laboratory following vascular puncture. The serum IL-10 level was also evaluated in 20 healthy and 30 at-risk control subjects. The mean serum level of IL-10 was significantly higher in the AMI patients than in either group of controls (all values of p<0.0001). Patients with a high serum IL-10 level (≥30 pg/ml) had a significantly lower left ventricular ejection fraction (LVEF) (defined as <50%), significantly higher incidence of cardiogenic shock, higher white blood cell (WBC) count, more advanced congestive heart failure (defined as New York Heart Association function classification of ≥3), and increased 30-day mortality than those patients with a low serum IL-10 level (<30 pg/ml) (all values of p<0.0001). Multiple stepwise logistic regression analysis demonstrated that a high serum IL-10 level, together with low LVEF, high WBC count and unsuccessful reperfusion, was independently predictive of increased 30-day mortality (all values of p<0.005). Conclusion In patients with ST-se AMI, the serum IL-10 level is a major independent predictor of 30-day mortality and should be used for early risk stratification following acute myocardial infarction. (Circ J 2007; 71: 1086 - 1091)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 71 (7), 1086-1091, 2007

    一般社団法人 日本循環器学会

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