Association of Epicardial, Visceral, and Subcutaneous Fat With Cardiometabolic Diseases

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  • Sato Fumi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University Department of Cardiology, KKR Otemae Hospital
  • Maeda Norikazu
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University
  • Yamada Takayuki
    Department of Cardiology, KKR Otemae Hospital
  • Namazui Hideyuki
    Department of Cardiology, KKR Otemae Hospital
  • Fukuda Shiro
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Natsukawa Tomoaki
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University Senri Critical Care Medical Center, Osaka Saiseikai Senri Hospital
  • Nagao Hirofumi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Murai Jun
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University Department of Internal Medicine, Kawasaki Hospital
  • Masuda Shigeki
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Tanaka Yoshimitsu
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Obata Yoshinari
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Fujishima Yuya
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Nishizawa Hitoshi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Funahashi Tohru
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University
  • Shimomura Iichiro
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University

書誌事項

公開日
2018
資源種別
journal article
DOI
  • 10.1253/circj.cj-17-0820
公開者
一般社団法人 日本循環器学会

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説明

<p>Background:Excess of visceral fat is a central factor in the pathogenesis of metabolic syndrome (MetS) and atherosclerosis. However, little is known about how much epicardial fat affects cardiometabolic disorders in comparison with visceral or subcutaneous fat.</p><p>Methods and Results:Participants suspected as having angina pectoris underwent cardiac computed tomography (CT) imaging. Of them, 374 subjects were analyzed the association of clinical characteristics and CT-based fat distribution measured as epicardial fat volume (EFV), visceral fat area (VFA), and subcutaneous fat area (SFA). EFV was highly associated with VFA (R=0.58). Serum adiponectin was significantly decreased in high VFA subjects (VFA ≥100 cm2) and was also reduced in the high EFV group (EFV ≥80 cm3). Among the low VFA groups, the numbers of subjects with diabetes and coronary atherosclerosis were increased in high EFV group. Among the low EFV groups, the numbers of subjects with diabetes, hyperuricemia, and coronary atherosclerosis were increased among the high VFA subjects. In an age-, sex-, and body mass index (BMI)-adjusted model, EFV was associated with dyslipidemia and MetS, and VFA was significantly associated with hypertension, dyslipidemia, MetS, and coronary atherosclerosis, while SFA was not related with coronary risks and atherosclerosis.</p><p>Conclusions:Epicardial fat accumulation may be a risk for coronary atherosclerosis in subjects without visceral fat accumulation. Visceral fat is the strongest risk for cardiometabolic diseases among the 3 types of fat depot.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 82 (2), 502-508, 2018

    一般社団法人 日本循環器学会

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