Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community　– The Hisayama Study –

DOI Web Site Web Site PubMed 被引用文献7件 参考文献30件
  • Takae Keita
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Nagata Masaharu
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Hata Jun
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
  • Mukai Naoko
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
  • Hirakawa Yoichiro
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Yoshida Daigo
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
  • Kishimoto Hiro
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University
  • Tsuruya Kazuhiko
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Kitazono Takanari
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
  • Kiyohara Yutaka
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
  • Ninomiya Toshiharu
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University

この論文をさがす

抄録

<p>Background:Growing evidence suggests that high serum uric acid (SUA) levels are causally related to increased risk of chronic kidney disease (CKD). However, few studies have investigated the influence of elevated SUA levels on the incidence of kidney dysfunction and albuminuria separately in community-based populations.</p><p>Methods and Results:A total of 2,059 community-dwelling Japanese subjects aged ≥40 years without CKD were followed for 5 years. CKD was defined as kidney dysfunction (estimated glomerular filtration rate <60 ml/min/1.73 m2) or albuminuria (urine albumin-creatinine ratio ≥30 mg/g). The odds ratio (OR) for the development of CKD was estimated according to quartiles of SUA (≤4.0, 4.1–4.9, 5.0–5.8, and ≥5.9 mg/dl). During the follow-up, 396 subjects developed CKD, of whom 125 had kidney dysfunction and 312 had albuminuria. The multivariable-adjusted risk of developing CKD increased with higher SUA levels (OR 1.00 [reference] for ≤4.0, 1.21 [95% confidence interval, 0.84–1.74] for 4.1–4.9, 1.47 [1.01–2.17] for 5.0–5.8, and 2.10 [1.37–3.23] for SUA ≥5.9 mg/dl, respectively). Similarly, there were positive associations between SUA level and the adjusted risk of developing kidney dysfunction (OR 1.00 [reference], 2.30 [1.10–4.82], 2.81 [1.34–5.88], and 3.73 [1.65–8.44]) and albuminuria (1.00 [reference], 1.12 [0.76–1.65], 1.35 [0.90–2.03], and 1.81 [1.14–2.87], respectively).</p><p>Conclusions:Higher SUA levels were a significant risk factor for the development of both kidney dysfunction and albuminuria in a general Japanese population. (Circ J 2016; 80: 1857–1862)</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 80 (8), 1857-1862, 2016

    一般社団法人 日本循環器学会

被引用文献 (7)*注記

もっと見る

参考文献 (30)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ