Roles of Xenobiotic Receptors in Vascular Pathophysiology

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  • Xiao Lei
    Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University
  • Zhang Zihui
    Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University
  • Luo Xiaoqin
    Cardiovascular Research Center, School of Medicine, Xi’an Jiaotong University Department of Public Health, School of Medicine, Xi’an Jiaotong University Nutrition and Food Safety Engineering Research Center of Shaanxi Province, School of Medicine, Xi’an Jiaotong University

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The pregnane X receptor (PXR) and constitutive androstane receptor (CAR), 2 closely related and liver-enriched members of the nuclear receptor superfamily, and aryl hydrocarbon receptor (AhR), a nonnuclear receptor transcription factor (TF), are major receptors/TFs regulating the expression of genes for the clearance and detoxification of xenobiotics. They are hence defined as “xenobiotic receptors”. Recent studies have demonstrated that PXR, CAR and AhR also regulate the expression of key proteins involved in endobiotic responses such as the metabolic homeostasis of lipids, glucose, and bile acid, and inflammatory processes. It is suggested that the functions of PXR, CAR and AhR may be closely implicated in the pathogeneses of metabolic vascular diseases, such as hyperlipidemia, atherogenesis, and hypertension. Therefore, manipulation of the activities of these receptors may provide novel strategies for the treatment of vascular diseases. Here, we review the pathophysiological roles of PXR, CAR and AhR in the vascular system. (Circ J 2014; 78: 1520–1530)

収録刊行物

  • Circulation Journal

    Circulation Journal 78 (7), 1520-1530, 2014

    一般社団法人 日本循環器学会

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