Metabolomic Analysis in Heart Failure

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  • Ikegami Ryutaro
    Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences
  • Shimizu Ippei
    Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences Division of Molecular Aging and Cell Biology, Niigata University Graduate School of Medical and Dental Sciences
  • Yoshida Yohko
    Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences Division of Molecular Aging and Cell Biology, Niigata University Graduate School of Medical and Dental Sciences
  • Minamino Tohru
    Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences

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<p>It is thought that at least 6,500 low-molecular-weight metabolites exist in humans, and these metabolites have various important roles in biological systems in addition to proteins and genes. Comprehensive assessment of endogenous metabolites is called metabolomics, and recent advances in this field have enabled us to understand the critical role of previously unknown metabolites or metabolic pathways in the cardiovascular system. In this review, we will focus on heart failure and how metabolomic analysis has contributed to improving our understanding of the pathogenesis of this critical condition.</p>

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