Postoperative Hyperglycemia and Atrial Fibrillation After Coronary Artery Bypass Graft Surgery

  • Tatsuishi Wataru
    Department of Cardiovascular Surgery, Tokyo Women’s Medical University, Medical Center East Department of Cardiovascular Surgery, Gunma Prefectural Cardiovascular Center
  • Adachi Hitoshi
    Department of Cardiology, Gunma Prefectural Cardiovascular Center
  • Murata Makoto
    Department of Cardiology, Gunma Prefectural Cardiovascular Center
  • Tomono Junichi
    Department of Cardiology, Gunma Prefectural Cardiovascular Center
  • Okonogi Shuichi
    Department of Cardiovascular Surgery, Gunma Prefectural Cardiovascular Center
  • Okada Syuichi
    Department of Cardiovascular Surgery, Gunma Prefectural Cardiovascular Center
  • Hasegawa Yutaka
    Department of Cardiovascular Surgery, Gunma Prefectural Cardiovascular Center
  • Ezure Masahiko
    Department of Cardiovascular Surgery, Gunma Prefectural Cardiovascular Center
  • Kaneko Tatsuo
    Department of Cardiovascular Surgery, Gunma Prefectural Cardiovascular Center
  • Ohshima Shigeru
    Department of Cardiology, Gunma Prefectural Cardiovascular Center

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Background:Postoperative atrial fibrillation (AF) is a common complication following coronary artery bypass grafting (CABG). We investigated the risk factors for postoperative AF and analyzed the relationship between blood sugar concentration (BS) and AF after CABG.Methods and Results:A total of 199 consecutive patients who underwent isolated CABG were retrospectively examined and classified according to the presence (n=95) or absence (n=104) of postoperative AF. On univariate analysis mean postoperative BS (P<0.001), postoperative drainage volume (P<0.001), age (P=0.034), presence of diabetes mellitus (DM; P=0.004), and postoperative estimated glomerular filtration rate (P=0.032) were significant risk factors for postoperative AF. On multivariate analysis mean postoperative BS (OR, 1.041; 95% CI: 1.008–1.079; P<0.001), postoperative drainage volume (OR, 1.003; 95% CI: 1.001–1.006; P=0.001), and age (OR, 1.040; 95% CI: 1.002–1.083; P=0.041) were significant risk factors for postoperative AF. Postoperative AF often occurred in patients with high postoperative BS, irrespective of DM. The BS cut-off that predicted postoperative AF occurrence was 180 mg/dl. A strong positive correlation existed between the time of the maximum postoperative BS and AF onset time (ρ=0.746).Conclusions:Mean postoperative BS and postoperative drainage volume are risk factors for AF after CABG. AF was strongly associated with maximum postoperative BS. Intensive glycemic control could reduce AF occurrence after CABG. (Circ J 2015; 79: 112–118)

収録刊行物

  • Circulation Journal

    Circulation Journal 79 (1), 112-118, 2014

    一般社団法人 日本循環器学会

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