Useful Computed Tomography Score for Estimation of Early Neurologic Outcome in Post-Cardiac Arrest Patients With Therapeutic Hypothermia

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  • Lee Kyu Sun
    Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center
  • Lee Sung Eun
    Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center
  • Choi Jun Young
    Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center
  • Gho Yu-Rha
    Department of Emergency Medicine, Ajou University School of Medicine, Ajou University Medical Center
  • Chae Minjung Kathy
    Department of Emergency Medicine, Ajou University School of Medicine, Ajou University Medical Center
  • Park Eun Jung
    Department of Emergency Medicine, Ajou University School of Medicine, Ajou University Medical Center
  • Choi Mun Hee
    Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center
  • Hong Ji Man
    Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center

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<p>Background:The Alberta Stroke Program Early CT Score (ASPECTS) is used to assess early ischemic stroke damage. This study compared bilateral ASPECTS (ASPECTS-b) with the gray:white matter ratio (GWR) and quantitative regional abnormality (QRA) to evaluate the prognostic utility of early computed tomography (CT) findings in post-cardiac arrest patients.</p><p>Methods and Results:Out-of-hospital cardiac arrest patients with return of spontaneous circulation (ROSC) who underwent brain CT (<6 h after onset) and therapeutic hypothermia were recruited from a university hospital over a 2-year period. General demographics, ROSC characteristics, ASPECTS-b (total score=20 points), GWR, and QRA were assessed. Multivariate logistic regression analysis was used to predict neurologic outcome using cerebral performance category (CPC) at 1 month. The study population was divided into good (n=20; CPC 1–2) and poor (n=47; CPC 3–5) outcome groups. The good (vs. poor) outcome group was younger (mean [±SD] age 46.7±11.8 vs. 60.3±17.2 years; P=0.002) and had more initial shockable rhythms (40.0% vs. 8.5%; P=0.002). In addition, the good outcome group had a higher mean ASPECTS-b score (15.3±2.7 vs. 9.0±4.9; P<0.001), despite no differences in QRA and mean GWR. Age and ASPECTS-b were independent predictors of outcome after adjusting for potential confounders.</p><p>Conclusions:These findings suggest that an initial CT score (ASPECTS-b) could help estimate early neurologic outcomes in post-cardiac arrest patients treated with therapeutic hypothermia.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 81 (11), 1628-1635, 2017

    一般社団法人 日本循環器学会

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