Epidemiology and Clinical Profile of Takotsubo Cardiomyopathy
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- Sharkey Scott W.
- Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital
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- Maron Barry J.
- Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital the Hypertrophic Cardiomyopathy Center
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First described in Japan over 2 decades ago, takotsubo cardiomyopathy (TTC) has emerged as a unique cardiomyopathy with world-wide recognition, mimicking acute coronary syndrome. In early TTC experience, typical patients were older women, with a triggering emotional event, ST-segment elevation, and apical ballooning left ventricular (LV) contraction pattern. However, TTC is now more heterogeneous, occurring in males and younger individuals, without ST-segment elevation, as a spontaneous event in the absence of a trigger, and with diverse LV contraction patterns. Furthermore, TTC is more common than initially thought, now constituting 10% of women with suspected acute coronary syndrome. TTC is also associated with a broader range of psychological or physical triggers, including presentation during outpatient medical evaluations or hospitalization for acute illness. Although TTC has been considered a benign condition, it now carries a small but important risk for adverse outcomes, including cardiac arrest in 5%. Hemodynamic instability requiring intervention with vasopressor drugs or intra-aortic balloon pump is necessary in 15% and in-hospital mortality is approximately 5%, largely because of refractory cardiogenic shock or irreversible major comorbid conditions. Although complete cardiac recovery usually occurs rapidly, post-hospital survival may be less than the general population of similar age, largely because of concomitant illnesses. TTC may reoccur in up to 10% of patients, but β-blocking drugs are not absolutely preventive for initial or subsequent events. (Circ J2014;78:2119–2128)
収録刊行物
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- Circulation Journal
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Circulation Journal 78 (9), 2119-2128, 2014
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680083555072
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- NII論文ID
- 130004677626
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- NII書誌ID
- AA11591968
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- COI
- 1:STN:280:DC%2BC2cbpsVGlug%3D%3D
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 025704065
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- PubMed
- 25099475
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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