Clinical and Angiographic Evaluation of the Resolute Zotarolimus-Eluting Coronary Stent in Japanese Patients
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- Saito Shigeru
- Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital
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- Maehara Akiko
- Imaging Core Laboratory, Columbia University College of Physicians and Surgeons Data Coordinating Center Cardiovascular Research Foundation
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- Vlachojannis Georgios J.
- Cardiology, Mount Sinai Medical Center
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- Parise Helen
- Data Coordinating Center Cardiovascular Research Foundation
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- Mehran Roxana
- Cardiology, Mount Sinai Medical Center
Bibliographic Information
- Other Title
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- Clinical and Angiographic Evaluation of the Resolute Zotarolimus-Eluting Coronary Stent in Japanese Patients : Long-Term Outcome in the RESOLUTE Japan and RESOLUTE Japan Small Vessel Study
- – Long-Term Outcome in the RESOLUTE Japan and RESOLUTE Japan Small Vessel Study –
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Abstract
Background:This study evaluated the safety and efficacy of the RESOLUTETMzotarolimus-eluting stent (R-ZES; Medtronic, Inc, Santa Rosa, CA, USA) in Japanese patients for the treatment of de novo native coronary lesions.Methods and Results:Both RESOLUTE Japan (R-Japan) and RESOLUTE Japan Small Vessel Study (R-Japan SVS) were prospective, multicenter, single-arm observational studies. R-Japan enrolled 100 patients (reference vessel diameter, 2.5–3.5 mm) and R-Japan SVS enrolled 65 patients (at least 1 lesion suitable for 2.25-mm stent) treated with R-ZES. In R-Japan, in-stent late lumen loss (LLL; the primary endpoint) at 8 months was 0.12±0.22 mm and volume obstruction on intravascular ultrasound was 2.33±3.51%. At 4 years, there were no cases of clinically driven target lesion revascularization (TLR); the target lesion failure (TLF; composite of cardiac death, target vessel myocardial infarction, and clinically driven TLR) was 5.6% (5/90). In R-Japan SVS, in-stent LLL at 9 months was 0.27±0.33 mm, TLF (primary endpoint) was 4.6% (3/65), without incidence of TLR. At 3 years, TLF was 7.9% (5/63) and clinically driven TLR, 3.2% (2/63).Conclusions:R-Japan and R-Japan SVS demonstrate substantial suppression of neointimal hyperplasia, low LLL, and excellent and sustained long-term clinical outcome with R-ZES in Japanese patients. (Circ J 2015; 79: 96–103)
Journal
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- Circulation Journal
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Circulation Journal 79 (1), 96-103, 2014
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390282680083608960
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- NII Article ID
- 130004712960
- 40020311814
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL BIB ID
- 026000863
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- PubMed
- 25428602
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed