Comparison of the First- and Second-Generation Limus-Eluting Stents for Bifurcation Lesions From a Korean Multicenter Registry : Different Efficacy in Left Main Bifurcation or 2-Stent Technique
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- Cho Youngjin
- Cardiovascular Center, Seoul National University Hospital
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- Koo Bon-Kwon
- Cardiovascular Center, Seoul National University Hospital
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- Song Young Bin
- Division of Cardiology, Samsung Medical Center, Sungkyunkwan University School of Medicine
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- Hahn Joo-Yong
- Division of Cardiology, Samsung Medical Center, Sungkyunkwan University School of Medicine
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- Choi Seung-Hyuk
- Division of Cardiology, Samsung Medical Center, Sungkyunkwan University School of Medicine
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- Gwon Hyeon-Cheol
- Division of Cardiology, Samsung Medical Center, Sungkyunkwan University School of Medicine
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- Rha Seung Woon
- Korea University Guro Hospital
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- Yu Cheol Woong
- Sejong General Hospital
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- Park Jong-Seon
- Yeungnam University Hospital
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- Bae Jang-Ho
- Konyang University Hospital
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- Lee Jae-Hwan
- Chungnam National University Hospital
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- Jeong Myung-Ho
- Chonnam National University Hospital
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- Yoon Jung Han
- Yonsei University Wonju College of Medicine
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- Jang Yangsoo
- Yonsei University Severance Hospital
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- Kim Hyo-Soo
- Cardiovascular Center, Seoul National University Hospital
書誌事項
- タイトル別名
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- Comparison of the First- and Second-Generation Limus-Eluting Stents for Bifurcation Lesions From a Korean Multicenter Registry
- – Different Efficacy in Left Main Bifurcation or 2-Stent Technique –
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Background:There are limited data on the relative efficacy of 1st- vs. 2nd-generation limus-eluting stents in bifurcation lesions.Methods and Results:Our analysis of a Korean multicenter registry for bifurcated coronary lesions enrolled 1,762 patients treated with 2nd-generation everolimus-eluting stent (EES, n=348) or 1st-generation sirolimus-eluting stents (SES, n=1,414). In the overall population, EES was comparable to SES regarding major adverse cardiac events (MACE: composite of cardiac death, nonfatal myocardial infarction, and target vessel revascularization (TVR)), cardiac death, and TVR rates within a 2-year follow-up. In 1:3 propensity score-matched populations, EES showed a significantly lower MACE rate compared with SES (HR [95% CI], 0.53 [0.29–0.97]; P=0.039), mainly through a reduction in repeat revascularization (HR [95% CI], 0.47 [0.24–0.92]; P=0.027). EES was superior to SES in reducing TVR in patients with left main (LM) lesions (HR [95% CI], 0.21 [0.06–0.67]; P=0.008) or in patients treated with 2-stent technique PCI (HR [95% CI], 0.28 [0.09–0.91]; P=0.035). There was no difference in clinical outcomes between 2 stents in a non-LM bifurcation lesion or in patients treated with a 1-stent technique.Conclusions:At 2-year follow-up, 1st- and 2nd-generation limus-eluting stents showed comparable clinical outcomes in general bifurcation lesions. EES was superior to SES after matching by propensity score, especially in patients with LM bifurcation or in those treated by a 2-stent technique. (Circ J 2015; 79: 544–552)
収録刊行物
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- Circulation Journal
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Circulation Journal 79 (3), 544-552, 2015
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680083688448
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- NII論文ID
- 130004927092
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 026186948
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- PubMed
- 25746538
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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