Plasma Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 as a Novel Prognostic Biomarker in Patients With ST-Segment Elevation Acute Myocardial Infarction

  • Higuma Takumi
    Department of Cardiology, Hirosaki University Graduate School of Medicine
  • Abe Naoki
    Department of Cardiology, Hirosaki University Graduate School of Medicine
  • Tateyama Syunta
    Department of Cardiology, Hirosaki University Graduate School of Medicine
  • Endo Tomohide
    Department of Cardiology, Hirosaki University Graduate School of Medicine
  • Shibutani Shuji
    Department of Cardiology, Hirosaki University Graduate School of Medicine
  • Yokoyama Hiroaki
    Department of Cardiology, Hirosaki University Graduate School of Medicine
  • Hanada Kenji
    Department of Cardiology, Hirosaki University Graduate School of Medicine
  • Yamada Masahiro
    Department of Cardiology, Hirosaki University Graduate School of Medicine
  • Tomita Hirofumi
    Department of Cardiology, Hirosaki University Graduate School of Medicine
  • Hanada Hiroyuki
    Department of Cardiology, Hirosaki University Graduate School of Medicine
  • Osanai Tomohiro
    Department of Cardiology, Hirosaki University Graduate School of Medicine
  • Kume Noriaki
    Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
  • Okumura Ken
    Department of Cardiology, Hirosaki University Graduate School of Medicine

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Background:Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) level is a reliable prognostic biomarker in acute coronary syndrome. However, it is unclear whether its plasma level at acute phase is related to the long-term prognosis in patients with ST-segment elevation acute myocardial infarction (STEMI).Methods and Results:We prospectively examined the relation between plasma sLOX-1 level on admission and prognosis in 153 consecutive STEMI patients admitted within 24 h of onset. Primary percutaneous coronary intervention was performed in 144 patients. The patients were divided into 2 groups by the median value (71 pg/ml) of plasma sLOX-1 level on admission [sLOX-1 level ≤71 pg/ml (n=77) and >71 pg/ml (n=76)], and were followed for median of 1,156 days. All-cause mortality and the combined endpoints of major adverse cardiovascular events (MACE) defined as cardiovascular mortality and recurrent MI were both significantly higher in patients with sLOX-1 values above median than in those below median (25.0% vs. 3.9%, P<0.001, and 19.4% vs. 6.5%, P=0.019 by log-rank test, respectively). Even after adjustment for confounders, a level of sLOX-1 above median was an independent predictor for all-cause mortality (hazard ratio (HR): 5.893; 95% confidence interval (CI): 1.665–20.854, P=0.006) and MACE (HR: 3.457; 95% CI: 1.164–10.270, P=0.030).Conclusions:Elevated plasma sLOX-1 level on admission independently predicts long-term all-cause mortality and MACE after STEMI. (Circ J 2015; 79: 641–648)

収録刊行物

  • Circulation Journal

    Circulation Journal 79 (3), 641-648, 2015

    一般社団法人 日本循環器学会

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