FOCUS REVIEWS ON CARDIOVASCULAR PROTECTION : Ca²⁺-Activated K⁺ Channels as Therapeutic Targets for Myocardial and Vascular Protection

DOI Web Site Web Site PubMed 参考文献63件
  • Clements Richard T.
    Department of Surgery, Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University
  • Terentyev Dmitry
    Department of Medicine, Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University
  • Sellke Frank W.
    Department of Surgery, Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University

書誌事項

タイトル別名
  • Ca<sup>2+</sup>-Activated K<sup>+</sup> Channels as Therapeutic Targets for Myocardial and Vascular Protection

この論文をさがす

抄録

Small- and large-conductance Ca2+-activated K+channels (SKCa and BKCa, respectively) may be important targets for therapeutic interventions in a variety of cardiac conditions. In cardiomyocytes, BKCa channels are localized to mitochondria where they beneficially modulate reactive oxygen species, mitochondrial Ca2+, and respiration. In vascular smooth muscle cells, BKCa channels regulate vascular tone and promote vasodilation. Activation of BKCa channels has demonstrated significant cardioprotection following ischemic injury, including improved function and reduced infarct size. SKCa channels are expressed in both the membrane and mitochondria of cardiomyocytes. Modulation of cardiomyocyte SKCa channels may be beneficial for arrhythmia, heart failure, and ischemia. Mitochondrial SKCa channels may provide similar benefit to BKCa channels. In addition, activation of SKCa channels on the endothelium promotes vasodilation. This mini-review focuses on the modulation of cardiomyocyte BKCa and SKCa channels for cardioprotection and briefly address associated potential therapeutic benefits in the coronary circulation. (Circ J 2015; 79: 455–462)

収録刊行物

  • Circulation Journal

    Circulation Journal 79 (3), 455-462, 2015

    一般社団法人 日本循環器学会

参考文献 (63)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ