In Vivo Assessment of Novel Stentless Valve in the Mitral Position
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- Kainuma Satoshi
- Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine
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- Kasegawa Hitoshi
- Sakakibara Heart Institute
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- Miyagawa Shigeru
- Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine
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- Nishi Hiroyuki
- Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine
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- Yaku Hitoshi
- Kyoto Prefectural University of Medicine
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- Takanashi Shuichiro
- Sakakibara Heart Institute
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- Hashimoto Kazuhiro
- The Jikei University
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- Okada Yukikatsu
- Kobe City Medical Center General Hospital
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- Nakatani Satoshi
- Division of Functional Diagnostics, Department of Health Sciences, Osaka University Graduate School of Medicine
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- Umezu Mitsuo
- Center for Advanced Biomedical Sciences, Waseda University
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- Daimon Takashi
- Department of Biostatistics, Hyogo College of Medicine
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- Sakaguchi Taichi
- Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine
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- Toda Koichi
- Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine
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- Sawa Yoshiki
- Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine
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Background:We conducted in vivo examinations of a newly designed stentless mitral valve (SMV), formed by suturing 2 leaflets with the “legs” serving as chorda tendinea, made from bovine pericardium, to a flexible ring.Methods and Results:Seven pigs underwent implantation of the SMV constructed with a 23-mm (n=5) or 25-mm (n=2) Duran ring. Baseline echocardiography examinations were used to evaluate the annular anteroposterior diameter, and distance between the mitral annulus (MA) and papillary muscles (PMs) to determine SMV-leg length. After removing the native valve, the SMV-legs were fixed to the anterior and posterior PMs, followed by fixation of the ring to the native MA. Immediately after surgery, all animals presented none or trivial mitral regurgitation, with mean and peak trans-SMV pressure gradient values of 1.9±0.8 and 6.0±3.1 mmHg, respectively. The mean length of the SMV-leg was 19.4±3.9 mm, which correlated with the distance between anterior and posterior MA-PM (r=0.96 and 0.94, respectively, P<0.01 for both). The discrepancy between the anteroposterior diameter of the ring (outside diameter) and that of the native valve was 1.0±2.9 mm, which correlated with the trans-SMV pressure gradient (r=0.81, P=0.025).Conclusions:In our preliminary study, the SMV demonstrated excellent diastolic inflow dynamics and closing function in vivo. Preoperative precise assessment of MV configuration may serve as a basis for selection of appropriate ring size and SMV-leg length. (Circ J 2015; 79: 553–559)
収録刊行物
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- Circulation Journal
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Circulation Journal 79 (3), 553-559, 2015
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680083735936
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- NII論文ID
- 130004927111
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 026186967
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- PubMed
- 25746539
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可