Role of Gut-Derived Protein-Bound Uremic Toxins in Cardiorenal Syndrome and Potential Treatment Modalities

DOI Web Site Web Site PubMed 被引用文献4件 参考文献118件

この論文をさがす

抄録

Uremic toxins have been increasingly recognized as a crucial missing link in the cardiorenal syndrome. Advances in dialysis technologies have contributed to an enormous improvement in uremic toxin removal, but removal of protein-bound uremic toxins (PBUTs) by current conventional dialysis remains problematic because of their protein-binding capacity. Most PBUTs that have been implicated in cardiorenal toxicity have been demonstrated to be derived from a colonic microbiota metabolism pathway using dietary amino acids as a substrate. Currently, indoxyl sulfate and p-cresyl sulfate are the most extensively investigated gut-derived PBUTs. Strong evidence of adverse clinical outcomes, as well as biological toxicity on the kidney and cardiovascular system attributable to these toxins, has been increasingly reported. Regarding their site of origin, the colon has become a potential target for treatment of cardiorenal syndrome induced by gut-derived PBUTs. (Circ J 2015; 79: 2088–2097)

収録刊行物

  • Circulation Journal

    Circulation Journal 79 (10), 2088-2097, 2015

    一般社団法人 日本循環器学会

被引用文献 (4)*注記

もっと見る

参考文献 (118)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ