Increasing Risk of Osteoporotic Fracture Is Associated With Vascular Dysfunction and Abnormal Vascular Structure in Both Men and Women

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  • Kajikawa Masato
    Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital
  • Oda Nozomu
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Kishimoto Shinji
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Maruhashi Tatsuya
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Iwamoto Yumiko
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Iwamoto Akimichi
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Matsui Shogo
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Aibara Yoshiki
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Mohamad Yusoff Farina Binti
    Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University
  • Hidaka Takayuki
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Kihara Yasuki
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Chayama Kazuaki
    Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Goto Chikara
    Department of Physical Therapy, Hiroshima International University
  • Noma Kensuke
    Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University
  • Nakashima Ayumu
    Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University
  • Taguchi Akira
    Department of Oral and Maxillofacial Radiology, Matsumoto Dental University
  • Higashi Yukihito
    Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University

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Abstract

<p>Background:Osteoporosis and cardiovascular disease are major public health problems. A number of clinical studies have shown a link between osteoporosis and cardiovascular disease, but there is no information on the associations of risk of osteoporotic fracture with vascular function and vascular structure.</p><p>Methods and Results:The risk of major osteoporotic fracture was calculated using the World Health Organization fracture risk assessment tool (FRAX); vascular function was assessed using flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID), and vascular structure was assessed on brachial artery intima-media thickness (IMT) in 414 subjects (241 men and 173 women) who underwent health examinations. On univariate regression, FRAX was negatively correlated with FMD (total, r=–0.16, P<0.001; men, r=–0.19, P=0.003; women, r=–0.25, P<0.001) and NID (total, r=–0.22, P<0.001; men, r=–0.19, P=0.003; women, r=–0.30, P<0.001) and was positively correlated with brachial artery IMT (total, r=0.12, P=0.02; men, r=0.22, P<0.001; women, r=0.33, P<0.001). On multivariate analysis FRAX remained an independent predictor of FMD, NID, and brachial artery IMT in both men and women.</p><p>Conclusions:Increase in the risk of osteoporotic fracture evaluated on FRAX is associated with vascular dysfunction and abnormal vascular structure in both men and women. Osteoporosis should be monitored in order to reduce the risk of cardiovascular events.</p>

Journal

  • Circulation Journal

    Circulation Journal 81 (6), 862-869, 2017

    The Japanese Circulation Society

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