Impact on Clinical Outcomes of Periodic Leg Movements During Sleep in Hospitalized Patients Following Acute Decompensated Heart Failure
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- Yatsu Shoichiro
- Department of Cardiovascular Medicine, Juntendo University School of Medicine
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- Kasai Takatoshi
- Department of Cardiovascular Medicine, Juntendo University School of Medicine Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
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- Suda Shoko
- Department of Cardiovascular Medicine, Juntendo University School of Medicine Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
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- Matsumoto Hiroki
- Department of Cardiovascular Medicine, Juntendo University School of Medicine Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
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- Shiroshita Nanako
- Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
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- Kato Mitsue
- Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
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- Kawana Fusae
- Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
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- Murata Azusa
- Department of Cardiovascular Medicine, Juntendo University School of Medicine
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- Kato Takao
- Department of Cardiovascular Medicine, Juntendo University School of Medicine
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- Hiki Masaru
- Department of Cardiovascular Medicine, Juntendo University School of Medicine
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- Daida Hiroyuki
- Department of Cardiovascular Medicine, Juntendo University School of Medicine
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Description
<p>Background:Periodic leg movements during sleep (PLM) are characterized by regularly recurring movement of the legs during sleep. Although PLM is common and a predictor of death in patients with chronic heart failure, the clinical significance of PLM in hospitalized patients with a reduced left ventricular ejection fraction (LVEF) following acute decompensated heart failure (ADHF) remains unknown.</p><p>Methods and Results:After initial improvement of acute signs and symptoms of ADHF, 94 consecutive patients with reduced LVEF who underwent polysomnography were enrolled. They were divided into 2 groups based on the presence or absence of severe PLM defined as PLM index ≥30. The risks for clinical events, composite of all-cause death and rehospitalization, were assessed using a stepwise multivariable Cox proportional model including variables showing P<0.10 in univariate analyses. Severe PLM was observed in 21 patients (22%). At a median follow-up of 5.2 months, 30 patients experienced clinical events (32%). In the multivariable analysis, the presence of severe PLM was significantly associated with increasing clinical events (hazard ratio, 2.16; 95% confidence interval, 1.03–4.54; P=0.042) independent of hemoglobin level and the severity of sleep-disordered breathing.</p><p>Conclusions:In hospitalized patients with systolic dysfunction following ADHF, severe PLM was prevalent and significantly associated with increased risk of death and/or rehospitalization.</p>
Journal
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- Circulation Journal
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Circulation Journal 81 (4), 495-500, 2017
The Japanese Circulation Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282680085113984
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- NII Article ID
- 130005475826
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL BIB ID
- 028063995
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- PubMed
- 28100870
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed