FOCUS REVIEWS ON HEART FAILURE : Direct Reprogramming of Fibroblasts into Cardiomyocytes for Cardiac Regenerative Medicine
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- Fu Ji-Dong
- Heart and Vascular Research Center, MetroHealth Campus of Case Western Reserve University Gladstone Institute of Cardiovascular Disease Roddenberry Center for Stem Cell Biology and Medicine at Gladstone
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- Srivastava Deepak
- Gladstone Institute of Cardiovascular Disease Roddenberry Center for Stem Cell Biology and Medicine at Gladstone Department of Pediatrics, University of California Department of Biochemistry and Biophysics, University of California
書誌事項
- タイトル別名
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- Direct Reprogramming of Fibroblasts into Cardiomyocytes for Cardiac Regenerative Medicine
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説明
Cardiac fibroblasts play critical roles in maintaining normal cardiac function and in cardiac remodeling during pathological conditions such as myocardial infarction (MI). Adult cardiomyocytes (CMs) have little to no regenerative capacity; damaged CMs in the heart after MI are replaced by cardiac fibroblasts that become activated and transform into myofibroblasts, which preserves the structural integrity. Unfortunately, this process typically causes fibrosis and reduces cardiac function. Directly reprogramming adult cardiac fibroblasts into induced CM-like cells (iCMs) holds great promise for restoring heart function. Direct cardiac reprogramming also provides a new research model to investigate which transcription factors and microRNAs control the molecular network that guides cardiac cell fate. We review the approaches and characterization of in vitro and in vivo reprogrammed iCMs from different laboratories, and outline the future directions needed to translate this new approach into a practical therapy for damaged hearts. (Circ J 2015; 79: 245–254)
収録刊行物
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- Circulation Journal
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Circulation Journal 79 (2), 245-254, 2015
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680085227648
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- NII論文ID
- 130004927056
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 026048755
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- PubMed
- 25744738
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可