Endarteritis Obliterans in the Pathogenesis of Buerger’s Disease From the Pathological and Immunohistochemical Points of View

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  • Kobayashi Masayoshi
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, Nagoya University
  • Sugimoto Masayuki
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, Nagoya University
  • Komori Kimihiro
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, Nagoya University

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Buerger’s disease (thromboangiitis obliterans) is considered to be a nonatherosclerotic, inflammatory, and vaso-occlusive disease, although the details of the mechanisms of pathogenesis remain unknown. The occurrence of the disease is strongly related to tobacco abuse and its progression is closely linked to continued smoking. The purpose of this review article is to demonstrate the pathological characteristics of arteries affected with Buerger’s disease from a possible immunoreactive point of view. In addition, we present the mechanisms for preserving the architecture of the arterial wall in affected vasculatures. Thereafter, we discuss the possibility that the pathogenesis of Buerger’s disease is a type of endarteritis obliterans, deeply connected to the Notch pathway, distinct from arteriosclerosis obliterans and other vasculitides. (Circ J 2014; 78: 2819–2826)

収録刊行物

  • Circulation Journal

    Circulation Journal 78 (12), 2819-2826, 2014

    一般社団法人 日本循環器学会

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