Echolucency of Carotid Plaque Is Useful for Assessment of Residual Cardiovascular Risk in Patients With Chronic Coronary Artery Disease Who Achieve LDL-C Goals on Statin Therapy
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- Uematsu Manabu
- Department of Internal Medicine II, Yamanashi University Hospital
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- Nakamura Takamitsu
- Department of Internal Medicine II, Yamanashi University Hospital
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- Sugamata Wataru
- Department of Internal Medicine II, Yamanashi University Hospital
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- Kitta Yoshinobu
- Department of Internal Medicine II, Yamanashi University Hospital
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- Fujioka Daisuke
- Department of Internal Medicine II, Yamanashi University Hospital
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- Saito Yukio
- Department of Internal Medicine II, Yamanashi University Hospital
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- Kawabata Ken-ichi
- Department of Internal Medicine II, Yamanashi University Hospital
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- Obata Jun-ei
- Department of Internal Medicine II, Yamanashi University Hospital
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- Watanabe Yosuke
- Department of Internal Medicine II, Yamanashi University Hospital
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- Watanabe Kazuhiro
- Department of Internal Medicine II, Yamanashi University Hospital
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- Kugiyama Kiyotaka
- Department of Internal Medicine II, Yamanashi University Hospital
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Abstract
Background: Ultrasound assessment of either intima-media thickness (IMT) or plaque echolucency of the carotid artery provides prognostic information on coronary events. This study examined the hypothesis that IMT and plaque echolucency of the carotid artery may remain useful for prediction of coronary events in patients with coronary artery disease (CAD) after achievement of LDL-C goals on statin therapy. Methods and Results: Ultrasound assessment of carotid maximum IMT (maxIMT) and plaque echolucency with integrated backscatter (IBS) analysis was performed in 357 chronic CAD patients with LDL-C <100mg/dl on statin therapy. All patients were prospectively followed up until the occurrence of one of the following coronary events: cardiac death, non-fatal myocardial infarction, or unstable angina pectoris requiring unplanned revascularization. During a mean follow-up of 32±18 months, 33 coronary events occurred. On multivariate Cox proportional hazards analysis, plaque echolucency (lower IBS value) was a significant predictor of coronary events (HR, 0.44; 95% CI: 0.29–0.73; P=0.009), whereas maxIMT was not. The addition of plaque echolucency to traditional risk factors improved net reclassification improvement (NRI) and integrated discrimination improvement (IDI; NRI, 0.59; P=0.0013; and IDI, 0.075; P=0.0009). Conclusions: Measurement of echolucency of the carotid artery was useful for assessment of residual coronary risk in CAD patients after LDL-C goal attainment on statin treatment. (Circ J 2014; 78: 151–158)<br>
Journal
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- Circulation Journal
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Circulation Journal 78 (1), 151-158, 2014
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390282680085617536
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- NII Article ID
- 130003382184
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- NII Book ID
- AA11591968
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- COI
- 1:CAS:528:DC%2BC2cXjt1yrsrs%3D
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- ISSN
- 13474820
- 13469843
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- NDL BIB ID
- 025112538
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- PubMed
- 24225306
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed