Vascular Function and Myocardial Performance Indices in Children Born Small for Gestational Age
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- Faienza Maria Felicia
- Department of Biomedical Sciences and Human Oncology, Section of Pediatrics, University “A. Moro”
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- Brunetti Giacomina
- Department of Basic and Medical Sciences, Neurosciences and Sense Organs, Section of Human Anatomy and Histology, University “A. Moro”
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- Delvecchio Maurizio
- Department of Biomedical Sciences and Human Oncology, Section of Pediatrics, University “A. Moro”
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- Zito Annapaola
- Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation, University “A. Moro”
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- De Palma Fabrizia
- Department of Biomedical Sciences and Human Oncology, Section of Pediatrics, University “A. Moro”
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- Cortese Francesca
- Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation, University “A. Moro”
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- Nitti Adriana
- Department of Biomedical Sciences and Human Oncology, Section of Pediatrics, University “A. Moro”
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- Massari Elena
- Department of Pediatric Cardiology, Giovanni XXIII Pediatric Hospital
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- Gesualdo Michele
- Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation, University “A. Moro”
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- Ricci Gabriella
- Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation, University “A. Moro”
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- Carbonara Santa
- Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation, University “A. Moro”
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- Giordano Paola
- Department of Biomedical Sciences and Human Oncology, Section of Pediatrics, University “A. Moro”
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- Cavallo Luciano
- Department of Biomedical Sciences and Human Oncology, Section of Pediatrics, University “A. Moro”
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- Scicchitano Pietro
- Cardiology Unit, Hospital “F. Perinei”
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- Ciccone Marco Matteo
- Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation, University “A. Moro”
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Abstract
Background:Small-for-gestational-age (SGA) children have increased cardiovascular risk, but the mediating factors are poorly understood. We hypothesized that birth size could affect the cardiovascular system since childhood in the absence of other risk factors. We investigated endothelial and myocardial function in SGA children with regular catch-up growth.Methods and Results:Biochemical markers, blood pressure, flow-mediated vasodilation (FMD), common carotid intima-media thickness (cIMT), anteroposterior diameter of the infrarenal abdominal aorta (APAO) and echocardiographic parameters of left and right ventricular (LV and RV) function were studied in 27 SGA and 25 appropriate-for-gestational-age (AGA) subjects. SGA subjects had a higher homeostasis model assessment index than controls (2.61±1.27 vs. 1.56±0.40, P=0.01), higher cIMT (0.51±0.04 mm vs. 0.45±0.07 mm, P=0.007) and APAO (1.31±1.35 cm vs. 1.30±0.16 cm, P=0.005), and lower FMD (10.11±4.17% vs. 12.34±4.28, P=0.04) than controls. On echocardiography SGA had higher Tei index both at LV and RV than controls (P=0.001). Reduced RV systolic function was also observed in SGA subjects.Conclusions:SGA subjects had vascular morphological and function abnormalities compared with AGA, which increase their cardiovascular risk profile. Furthermore, a subtle cardiac alteration in both RV and LV functions was seen in SGA patients compared with AGA. (Circ J 2016; 80: 958–963)
Journal
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- Circulation Journal
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Circulation Journal 80 (4), 958-963, 2016
The Japanese Circulation Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282680085757312
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- NII Article ID
- 130005139573
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL BIB ID
- 027203298
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- PubMed
- 26861187
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed