Retinal Neurotoxicity of Nitric Oxide Donors With Different Half-Life of Nitric Oxide Release: Involvement of N-Methyl-D-aspartate Receptor
-
- Takahata Kazue
- Institute of Research and Development, Fujimoto Pharmaceutical Corporation
-
- Katsuki Hiroshi
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
-
- Kume Toshiaki
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
-
- Ito Ken
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
-
- Tochikawa Yoshinaga
- Institute of Research and Development, Fujimoto Pharmaceutical Corporation
-
- Muraoka Shizuko
- Institute of Research and Development, Fujimoto Pharmaceutical Corporation
-
- Yoneda Fumio
- Institute of Research and Development, Fujimoto Pharmaceutical Corporation
-
- Kashii Satoshi
- Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University
-
- Honda Yoshihito
- Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University
-
- Akaike Akinori
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
この論文をさがす
抄録
We compared the degree of neurotoxic outcome in the retina exposed to three nitric oxide (NO) donors with different half-life of NO release. Intravitreal injection of NO donors resulted in a significant decrease in cell density in the ganglion cell layer and thinning of the inner plexiform layer in a half-life time-dependent manner. Concurrent injection of an NO-trapping reagent with an NO donor abolished NO donor-induced retinal damage. (+)-MK-801 also prevented NO-induced retinal damage, indicating that N-methyl-<sc>D</sc>-aspartate receptors are partly involved in NO-induced neurodegeneration. These results may be relevant to a pathogenic role of NO – glutamate receptor in several ophthalmic disorders.<br>
収録刊行物
-
- Journal of Pharmacological Sciences
-
Journal of Pharmacological Sciences 92 (4), 428-432, 2003
公益社団法人 日本薬理学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282680151814912
-
- NII論文ID
- 10011432515
-
- NII書誌ID
- AA11806667
-
- COI
- 1:CAS:528:DC%2BD3sXmvFGlsb4%3D
-
- ISSN
- 13478648
- 13478613
-
- NDL書誌ID
- 6656254
-
- PubMed
- 12939529
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可