Stress and Vascular Responses: Endothelial Dysfunction via Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1: Close Relationships With Oxidative Stress
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- Sakurai Kanako
- Department of Bioscience, National Cardiovascular Center Research Institute
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- Sawamura Tatsuya
- Department of Bioscience, National Cardiovascular Center Research Institute
Bibliographic Information
- Other Title
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- Endothelial Dysfunction via Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1: Close Relationships With Oxidative Stress
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Abstract
Endothelial dysfunction is associated with pathological vascular conditions including atherosclerosis, hypertension, and diabetes. The oxidatively modified form of low-density lipoprotein (LDL) is recognized as a major cause of endothelial dysfunction in atherogenesis. As the receptor for oxidized LDL in endothelial cells, we have identified the lectin-like oxidized LDL receptor-1 (LOX-1). LOX-1 is up-regulated by products of oxidative stresses and the molecules that induce oxidative stresses. Activation of LOX-1 induces the generation of reactive oxygen species and decreases NO released from endothelial cells. LOX-1 activation further induces the expression of endothelin-1, AT1 receptor, and cell adhesion molecules. Together with these properties, LOX-1 works as an adhesion molecule for activated platelets and neutrophils. Thus, LOX-1, within the close relationships between oxidative stress generation and response, enhances functional changes in endothelial cells that are relevant to the disturbed vascular homeostasis under pathological settings.<br>
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 91 (3), 182-186, 2003
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282680152857856
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- NII Article ID
- 130000073697
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 6490433
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- PubMed
- 12686739
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed