Mechanisms for the Anti-nociceptive Actions of the Descending Noradrenergic and Serotonergic Systems in the Spinal Cord

DOI Web Site PubMed 被引用文献42件 参考文献125件 オープンアクセス
  • Yoshimura Megumu
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Japan
  • Furue Hidemasa
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Japan

書誌事項

公開日
2006
資源種別
journal article
DOI
  • 10.1254/jphs.crj06008x
公開者
公益社団法人 日本薬理学会

この論文をさがす

説明

The sensation of pain plays a critical role as an alert and as a protection system against tissue damage from mechanical, chemical, and thermal stimuli. Despite the protective role of pain, the severity of pain sensation is markedly attenuated by the endogenous pain inhibitory systems that predominantly originate at the brain stem. Both behavioral and in vivo extracellular recording studies have sought the loci producing analgesia and clarification of the anti-nociceptive actions. Among those loci, the main descending systems to the spinal dorsal horn are noradrenergic and serotonergic. Although, in vivo studies have provided basic knowledge of these systems, the precise synaptic mechanisms underlying the analgesic actions have not yet been elucidated until recently. The newly developed in vitro slice and in vivo patch-clamp recordings have disclosed the synaptic mechanisms of the noradrenergic and serotonergic effects at the level of spinal dorsal horn. This paper reviews the anti-nociceptive action of these systems, while particularly focusing on the electrophysiological aspects of the systems at the single neuron level in the spinal dorsal horn as well as their origins and responsible receptor subtypes.<br>

収録刊行物

被引用文献 (42)*注記

もっと見る

参考文献 (125)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ