Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid Hemorrhage
-
- Nishihashi Tsuyoshi
- Pharmacology Division, RI Center, Kyoto University, Japan
-
- Trandafir Cristina C.
- Pharmacology Division, RI Center, Kyoto University, Japan
-
- Wang Aimin
- Pharmacology Division, RI Center, Kyoto University, Japan
-
- Ji Xu
- Pharmacology Division, RI Center, Kyoto University, Japan
-
- Shimizu Yoshiharu
- Department of Community Health, School of Medicine, Tokai University, Japan
-
- Kurahashi Kazuyoshi
- Pharmacology Division, RI Center, Kyoto University, Japan
Search this article
Abstract
Vasospasm after subarachnoid hemorrhage (SAH) is a serious complication and we have been investigating the relationship between vasoconstrictors and vasospasm after SAH. The present study was designed to investigate the vasocontractile responses to reactive oxygen species in isolated rat basilar arteries from the control and experimental SAH rats. Contractile responses to hydroxyl radicals in basilar arteries from SAH rats were 3 – 6-fold higher than those in control rats. The present results clearly indicate that hypersensitivity to hydroxyl radicals may contribute to the vasospasm after SAH.<br>
Journal
-
- Journal of Pharmacological Sciences
-
Journal of Pharmacological Sciences 100 (3), 234-236, 2006
The Japanese Pharmacological Society
- Tweet
Details 詳細情報について
-
- CRID
- 1390282680153241984
-
- NII Article ID
- 10018240436
-
- NII Book ID
- AA11806667
-
- ISSN
- 13478648
- 13478613
-
- NDL BIB ID
- 7858283
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed
