Characteristics of Attenuating Effects of Rebamipide, an Anti-ulcer Agent, on Oxidative Burst of Human Neutrophils
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- Shimoyama Tadashi
- First Department of Internal Medicine, Hirosaki University School of Medicine
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- Fukuda Shinsaku
- First Department of Internal Medicine, Hirosaki University School of Medicine
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- Liu Qiang
- Department of Hygiene, Hirosaki University School of Medicine
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- Fukuda Yoshihiro
- Department of Gastroenterology, Hyogo Medical College
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- Nakaji Shigeyuki
- Department of Hygiene, Hirosaki University School of Medicine
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- Sugawara Kazuo
- Department of Hygiene, Hirosaki University School of Medicine
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Abstract
The aim of this study was to characterize the effects of rebamipide on the oxidative burst of human neutrophils. The neutrophil oxidative burst was measured in the presence of rebamipide and cimetidine using lucigenin- or luminol-dependent chemiluminescence (LgCL or LmCL). Rebamipide inhibited the LmCL response stimulated with opsonized zymosan, 12-myristate 13-acetate phorbol, and calcium ionophore in a dose-dependent manner, but the LgCL response was inhibited when neutrophils were stimulated with opsonized zymosan. LmCL response was also dose-dependently attenuated by rebamipide even in the presence of cimetidine. Thus, addition of rebamipide to H2-receptor antagonists can be considered for the treatment of gastric mucosal injury associated with oxidative stress.<br>
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 91 (2), 153-157, 2003
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282680153620736
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- NII Article ID
- 130000073718
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- NII Book ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BD3sXhslCkt7c%3D
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 6581901
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- PubMed
- 12686760
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed