Dehydroepiandrosterone Sulfate Reduces Acoustic Injury of the Guinea-Pig Cochlea
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- Tabuchi Keiji
- Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- Murashita Hidekazu
- Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- Tobita Tadamichi
- Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- Oikawa Keiko
- Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- Tsuji Shigeki
- Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- Uemaetomari Isao
- Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- Hara Akira
- Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Description
The present study was performed to determine effects of dehydroepiandrosterone sulfate (DHEAS), a neurosteroid, on acoustic injury. Albino guinea pigs were exposed to a 2 kHz pure tone of 120 or 125 dB sound pressure level for 10 min immediately after intravenous administration of DHEAS. Statistically significant improvement in the compound action potential threshold shifts and in amplitude reduction of distortion-product otoacoustic emissions was observed 1 week after the acoustic overexposure in the animals treated with DHEAS. The present results suggest that DHEAS has a protective effect against acoustic injury of the cochlea.<br>
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 99 (2), 191-194, 2005
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282680153864832
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- NII Article ID
- 10025730930
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 7482379
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- PubMed
- 16210774
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed