Pharmacology of SEA0400, a Specific Inhibitor of the Na〔+〕-Ca〔2+〕 Exchanger

DOI Web Site PubMed 被引用文献8件 参考文献66件
  • Matsuda Toshio
    Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Koyama Yutaka
    Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Baba Akemichi
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University

書誌事項

タイトル別名
  • Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Pharmacology of SEA0400, a Specific Inhibitor of the Na+-Ca2+ Exchanger
  • Pharmacology of SEA0400 a Specific Inhibitor of the Na Ca 2 Exchanger

この論文をさがす

説明

The Na+-Ca2+ exchanger (NCX) is involved in regulation of intracellular Ca2+ concentration. A specific inhibitor of NCX has been required for clarification of the physiological and pathological roles of NCX. We have developed 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400), a highly potent and selective inhibitor of NCX. SEA0400 in the concentration range that inhibits NCX exhibits negligible affinities for the Ca2+ channels, Na+ channels, K+ channels, noradrenaline transporter, and 14 receptors; and it does not affect the activities of the store-operated Ca2+ channel, Na+-H+ exchanger, and several enzymes including Na+,K+-ATPase and Ca2+-ATPase. Furthermore, recent studies show that SEA0400 attenuates ischemia-reperfusion injury in the brain, heart, and kidney and radiofrequency lesion-induced edema in rat brain. These findings suggest that NCX plays a key role in ischemia-reperfusion injury and may be a target molecule for treatment of reperfusion injury-related diseases.<br>

収録刊行物

被引用文献 (8)*注記

もっと見る

参考文献 (66)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ